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The Best Spray to Kill Bed Bugs: An Exhaustive Guide

From the Puffy Editorial Team | 3 min read.
The Best Spray to Kill Bed Bugs: An Exhaustive Guide

Bed bugs: the very words can make your skin crawl. These tiny, resilient pests have a knack for turning our peaceful nights into sleepless ordeals. In the quest to eliminate them, sprays often emerge as a go-to solution.

But what is the best spray to kill bed bugs? In this article, we’ll separate myth from reality and provide you with a comprehensive guide to selecting the best bed bug sprays available.

Does Bug Spray Kill Bed Bugs?

Standard bug sprays are typically not effective against bed bugs. Many of these sprays are designed for flying insects or ants, and bed bugs have different vulnerabilities.

What You Need to Know

  • Chemical Composition: Regular bug sprays contain pyrethroids, which bed bugs are increasingly resistant to.
  • Specificity: Bug sprays are generally not designed to target bed bugs.

If you find that generic bug sprays are not effective, specialized mattresses like Puffy’s can be an excellent second line of defense. These mattresses are designed to be resistant to bed bugs and other pests.

What Can I Spray to Kill Bed Bugs?

So what can be used to defeat these sneaky invaders?

Effective Ingredients

  • Permethrin: Found in many dedicated bed bug sprays.
  • Piperonyl Butoxide: Often used in combination with other chemicals for increased potency.

Product Recommendations

  • EcoRaider Bed Bug Killer: Eco-friendly and non-toxic.
  • Ortho Home Defense: Provides up to 12 months of protection.

Does Roach Spray Kill Bed Bugs?

Not all insecticides are created equal. While roach sprays may kill on contact, they usually don’t provide long-lasting relief from bed bugs.

Why it’s Ineffective

  • Short-lived Results: Bed bugs often return after the effects wear off.
  • Safety Concerns: Roach spray fumes can be harmful to humans and pets.

Does Disinfectant Spray Kill Bed Bugs?

The simple answer is no, disinfectant sprays like Lysol or Clorox don’t kill bed bugs.

Reasons for Ineffectiveness

  • Contact Time: Disinfectants require prolonged contact time, which is impractical for bed bugs.
  • Toxicity: High levels of toxicity are dangerous to humans and pets.

Does Lysol Spray Kill Bed Bugs?

While Lysol may kill some bacteria and viruses, it’s not effective against bed bugs.

Why Lysol Doesn’t Work

  • Lack of Residual Effect: No lingering effects to deter bed bugs.
  • Not a Pesticide: Lysol is a disinfectant, not an insecticide.

Will Raid Flea Spray Kill Bed Bugs?

Flea sprays like Raid can be moderately effective but are not designed for bed bugs.


  • Not Specifically Formulated: Ingredients may not target bed bug physiology.
  • Temporary Effects: Any killed bugs are likely to be quickly replaced.

Can Raid Roach Spray Kill Bed Bugs?

Unfortunately, the answer is a qualified no.

Factors for Ineffectiveness

  • Inappropriate Chemicals: Not designed to combat bed bugs.
  • Limited Residual Impact: No long-term effects.

Check out Puffy mattress reviews from real customers and see how we compare with other brands.

Does Raid Spray Kill Bed Bugs?

General Raid spray, like its flea and roach-specific counterparts, is not an effective solution.

Ineffectiveness Explained

  • Limited Scope: Not designed for bed bugs.
  • Chemical Resistance: Bed bugs may be resistant to the chemicals used.

Aside from sprays, another surefire way to combat bed bugs is to invest in specialized bedding. Puffy mattresses, for instance, come with covers that can be easily removed and washed, offering a long-term solution.

Does Flea Spray Kill Bed Bugs?

Just like with Raid Flea Spray, general flea sprays aren’t specifically designed to kill bed bugs.

Why They Fall Short

  • Different Pests: Fleas and bed bugs have different physiologies.
  • Temporary Relief: Flea sprays lack residual effects needed for lasting bed bug control.


In the end, not all sprays are created equal, especially when it comes to bed bugs. To effectively rid yourself of these resilient pests, you need sprays specifically formulated for bed bugs.

Use our store locator to find the closest furniture or mattress store near you and feel the cloudlike comfort of our Puffy Mattress in person.

General insecticides or household cleaning products just won’t do the trick. For more sustainable, long-term solutions, you might also consider bed bug-resistant mattresses and covers. Your peaceful night’s sleep might depend on making the right choice.

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