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How to Clean Bodily Fluids from Mattress: Ensuring Hygiene and Comfort

From the Puffy Editorial Team | 5 min read.
How to Clean Bodily Fluids from Mattress: Ensuring Hygiene and Comfort

Dealing with bodily fluids on a mattress is a common yet challenging aspect of maintaining bedroom hygiene. Understanding how to effectively clean these fluids is crucial for ensuring a sanitary and comfortable sleeping area.

What Can Bodily Fluids Do to Your Mattress?

Bodily fluids can have several negative impacts on a mattress if not addressed promptly:

  1. Staining: Bodily fluids like sweat, urine, blood, and others can leave noticeable stains on the mattress fabric. These stains can be unsightly and difficult to remove if not treated quickly.

  2. Odor Development: Over time, fluids absorbed into a mattress can lead to unpleasant odors. These smells can be challenging to eliminate and may affect the overall freshness of your sleep environment.

  3. Bacterial and Mold Growth: Moisture from bodily fluids can seep into the deeper layers of the mattress, creating an ideal environment for bacteria and mold to grow. This not only causes health issues but can also lead to the deterioration of the mattress.

  4. Allergen Accumulation: Fluids can attract dust mites and other allergens, which thrive in damp environments. This can be problematic, especially for those with allergies or respiratory issues.

  5. Comfort and Support Issues: Excessive moisture can break down the materials inside a mattress, affecting its comfort and support levels over time.

How to Clean Bodily Fluids Off Mattress

To effectively remove bodily fluids from a mattress and mitigate their impact, follow these steps:

  1. Immediate Action: As soon as you notice a spill or stain, act quickly. Blot up as much liquid as possible with a clean, dry towel.

  2. Choose the Right Cleaner: For most bodily fluids, a mixture of mild detergent and water works well. For tougher stains like blood, consider using a hydrogen peroxide-based solution.

  3. Gentle Application: Apply the cleaning solution to the stained area using a spray bottle or a damp cloth. Avoid saturating the mattress, as excessive moisture can cause additional issues.

  4. Blotting the Stain: Gently blot the stain with the solution, starting from the outside and working inward to prevent the stain from spreading.

  5. Rinse Thoroughly: After cleaning, dab the area with a cloth dampened with clean water to rinse out any soap residue.

  6. Dry the Mattress: Allow the mattress to air dry completely. Use a fan to circulate air around the mattress or place it in a well-ventilated area.

  7. Deodorizing: If an odor persists, sprinkle baking soda over the cleaned area after it is dry, leave it for a few hours or overnight, and then vacuum it up.

  8. Repeat if Necessary: For stubborn stains, you may need to repeat the cleaning process.

For a simpler cleaning experience, Puffy mattresses offer advanced fabric technology that resists the absorption of liquids, making them easier to clean and maintain.

Interested in how Puffy stacks up against other brands? Check out our mattress comparisons: Puffy vs Purple, Puffy vs Nectar, Puffy vs Casper, Puffy vs Leesa, Puffy vs Saatva, Puffy vs DreamCloud, and Puffy vs Tuft and Needle.

How to Remove Bodily Fluid Stains from Mattress

Removing bodily fluid stains from a mattress can be a daunting task, but it’s essential for maintaining a clean and hygienic sleeping environment. Here’s how to tackle different types of fluid stains:

  1. Blood Stains:

    • Use cold water, as warm water can set the stain.
    • Apply a mixture of salt and cold water or a hydrogen peroxide solution directly to the stain.
    • Blot gently, then rinse with a damp cloth and blot dry.
  2. Urine Stains:

    • Mix a solution of vinegar and water or use an enzyme-based cleaner, which can break down the proteins in urine.
    • Spray or dab the solution onto the stain, let it sit for several minutes, then blot and rinse.
  3. Sweat Stains:

    • Create a paste using baking soda and water, and apply it to the stain.
    • After 30 minutes, remove the paste, then clean the area with a damp cloth.
  4. Vomit Stains:

    • Remove any solid matter first.
    • Clean the area with a mixture of baking soda, vinegar, and water. The baking soda helps to neutralize the acid in vomit.
  5. General Cleaning Tips:

    • Always blot stains rather than rubbing to avoid spreading them.
    • For all types of stains, ensure the mattress is completely dry after cleaning.

Check out Puffy mattress reviews from real customers and see how we compare with other brands.

Dispose of Mattress with Bodily Fluids

Sometimes a mattress with extensive or deeply ingrained bodily fluid stains may need to be disposed of. Here’s how to responsibly handle the disposal:

  1. Check Local Regulations:

    • Many areas have specific guidelines for mattress disposal, especially if they’re contaminated with bodily fluids.
  2. Professional Cleaning Attempt:

    • Before deciding to dispose of the mattress, consider if professional cleaning services could salvage it.
  3. Proper Disposal Methods:

    • If disposal is the only option, follow local guidelines for hazardous waste due to the potential biohazard nature of the fluids.
    • Some areas may require the mattress to be sealed in plastic before disposal.
  4. Consider Recycling Options:

    • Look for mattress recycling programs in your area. These programs can dismantle the mattress and recycle its components.
  5. Replacement Considerations:

    • When choosing a new mattress, consider one with a removable and washable cover or built-in protection against stains and moisture.

Replacing a severely soiled mattress? Consider a Puffy Lux Mattress for its durable design and ease of maintenance.

Additional Tips for Mattress Care and Maintenance

  • Regular Vacuuming: Helps remove dust, skin cells, and potential allergens.
  • Use Mattress Protectors: A waterproof mattress protector can prevent fluids from penetrating the mattress.
  • Routine Rotation: Regularly rotate the mattress to promote even wear and extend its lifespan.

Use our store locator to find the closest furniture or mattress store near you and feel the cloudlike comfort of our Puffy Mattress in person.


Cleaning bodily fluids from a mattress may not be the most pleasant task, but it’s essential for maintaining a clean, hygienic, and comfortable sleep environment. By following these guidelines, you can effectively tackle stains and odors, ensuring your mattress remains a welcoming and sanitary place to rest.

Make the Puffy
Lux Hybrid Mattress yours.

Relax into award-winning comfort with:

  • 6 layers of cloudlike luxury.
  • Medium-plush feel.
  • 101-night sleep trial.